The curious and curiouser Yotsuba moves to a new town with her dad. In the process of moving in, Yotsuba encounters things like swing sets and broken door handles, which all bring about a never-ending torrent of questions and shrieks of amazement. When she befriends her neighbors, they can't help but wonder where this strange little girl really came from, seeing how she's delighted by the most mundane, everyday things.
